EMP3
Sign in to saveAlso known as YMP, epithelial membrane protein 3
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule that is encoded by the myelin-related gene EMP3. EMP3 is a member of the peripheral myelin protein gene family 22-kDa (PMP22), which is mainly responsible for the formation of the sheath of compact myelin. Although the detailed functions and mechanisms of EMP3 still remain unclear, it is suggested that EMP3 is possibly epigenetically linked to certain carcinomas.
Gene data
EMP3- Name
- epithelial membrane protein 3 (MAM blood group)
- Type
- protein-coding
- Position
- 48,321,310–48,330,560 (+)
- Aliases
- YMP
- Ensembl
- ENSG00000142227
- RefSeq RNA
- NM_001313905.1, NM_001425.3, XM_011526605.4, XM_054320174.1
- RefSeq protein
- NP_001300834.1, NP_001416.1, XP_011524907.1, XP_054176149.1
The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
epithelial membrane protein 3 (MAM blood group)
- Symbol
- EMP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:48,321,310-48,330,560
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1090
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2014
- genomic end
- 48833810
- genomic start
- 48824766
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.33
- Commons category
- EMP3
Sources (4)
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Structure
- Function
- Tumorgenesis and carcinogenesis
- Primary breast carcinomas
- Hepatocellular carcinoma (HCC)
- Brain cancer
- Clinical significance
- References
Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule that is encoded by the myelin-related gene EMP3. EMP3 is a member of the peripheral myelin protein gene family 22-kDa (PMP22), which is mainly responsible for the formation of the sheath of compact myelin. Although the detailed functions and mechanisms of EMP3 still remain unclear, it is suggested that EMP3 is possibly epigenetically linked to certain carcinomas.
== Structure == thumb|left|The EMP3 structure based on the 163-amino acid sequence. Four yellow helices represent four transmembrane domains.
Excerpted from Wikipedia’s “EMP3” article, available under the CC BY-SA 4.0 licence.