endothelin
Sign in to saveAlso known as endothelium-dependent contracting factor, endothelium-derived contracting factor, endothelins
Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases.
Key facts
- Protein family.Symbol
- Endothelin
- Protein family.Name
- Endothelin family
- Protein family.image
- 1EDN human endothelin1 02.png
- Protein family.Pfam
- PF00322
- Protein family.InterPro
- IPR001928
- Protein family.Prosite
- PDOC00243
- Protein family.SCOP
- 1edp
- Protein family.OPM family
- 147
- Protein family.OPM protein
- 3cmh
- Protein.Name
- Endothelin 3
- Protein.HGNCid
- 3178
- Protein.Symbol
- EDN3
- Protein.EntrezGene
- 1907
- Protein.OMIM
- 131242
- Protein.RefSeq
- NM_000114
- Protein.UniProt
- P14138
- Protein.Chromosome
- 20
- Protein.Arm
- q
via Wikipedia infobox
Research
35,750 papersvia PubMed
~6 min read
Encyclopedic overview
8 sectionsContents
- Etymology
- Isoforms
- Mechanism of action and function
- Physiological effects
- Clinical significance
- Antagonists
- References
- External links
Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases.
Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, lungs, kidneys, and brain. As of 2018, endothelins remain under extensive basic and clinical research to define their roles in several organ systems.
Excerpted from Wikipedia’s “endothelin” article, available under the CC BY-SA 4.0 licence.