enediynes
Sign in to saveAlso known as enediyne
Enediynes are organic compounds containing two triple bonds and one double bond.
Research
1,878 papers- Anthraquinone-fused enediynes: discovery, biosynthesis and development.Natural product reports · 2022
- Synthesis and Biological Activity of Unnatural Enediynes.Current medicinal chemistry · 2017
- Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.Bioorganic & medicinal chemistry letters · 2015
- Jejucarbosides B-E, Chlorinated Cycloaromatized Enediynes, from a Marine Streptomyces sp.Marine drugs · 2023
- Synthesis and biological properties of maleimide-based macrocyclic lactone enediynes.Organic & biomolecular chemistry · 2022
via PubMed
~8 min read
Encyclopedic overview
14 sectionsContents
- Structure and reactivity
- Mechanism of action
- Biosynthesis
- Classes
- Nine-membered rings (chromoproteins)
- Neocarzinostatin
- C-1027
- Ten-membered rings
- Calicheamicins
- Esperamicins
- Dynemicins
- Golfomycin A
- See also
- References
Enediynes are organic compounds containing two triple bonds and one double bond.
Enediynes are most notable for their limited use as antitumor antibiotics (known as enediyne anticancer antibiotics). They are efficient at inducing apoptosis in cells, but cannot differentiate cancerous cells from healthy cells. Consequently, research is being conducted to increase the specificity of enediyne toxicity.
Excerpted from Wikipedia’s “enediynes” article, available under the CC BY-SA 4.0 licence.