Erythroferrone
Sign in to saveAlso known as protein FAM132B, ERFE, myonectin, complement C1q tumor necrosis factor-related protein 15, family with sequence similarity 132, member B, Myonectin
Erythroferrone is a protein hormone encoded in humans by the ERFE gene. Erythroferrone is produced by erythroblasts, inhibits the production of hepcidin in the liver, and so increases the amount of iron available for hemoglobin synthesis. Skeletal muscle secreted ERFE has been shown to maintain systemic metabolic homeostasis.
Protein · UniProt
Erythroferrone
- Gene
- ERFE
- Organism
- Homo sapiens (Human)
- Length
- 354 aa
- Molecular mass
- 37,279 Da
- Evidence
- 1: Evidence at protein level
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent acti…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
5 registered- UNKNOWNInflammation, Iron Deficiency and Anaemia Study 1London School of Hygiene and Tropical Medicine · NCT04097639
- COMPLETEDNew IR Biomarkers (Myokines) in Colombian PeopleUniversity of Los Andes, Columbia · NCT03244449
- COMPLETEDErythroferrone and Its Impact on Maternal and Neonatal Iron HomeostasisCornell University · NCT04517734
- UNKNOWNThe Relationship Between Myonectin Concentration and the Course of ST-segment Elevation Myocardial InfarctionMichał Jaśkiewicz · NCT05700773
- PHASE1UNKNOWNEvaluation of Erythroferrone as a New Biomarker of Erythropoesis Stimulating AgentsAssociation Athletes For Transparency · NCT03276910
Wikidata facts
- Instance of
- protein
Show 4 more facts
- biological process
- signal transduction
- found in taxon
- Homo sapiens
- cell component
- extracellular space
- exact match
- www.ncbi.nlm.nih.gov/protein/Q4G0M1
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Discovery
- Structure
- Function
- Regulation
- Clinical significance
- References
Erythroferrone is a protein hormone encoded in humans by the ERFE gene. Erythroferrone is produced by erythroblasts, inhibits the production of hepcidin in the liver, and so increases the amount of iron available for hemoglobin synthesis. Skeletal muscle secreted ERFE has been shown to maintain systemic metabolic homeostasis.
== Discovery == It was identified in 2014 in mice where the transcript was found in bone marrow, encoded by the mouse Fam132b gene. The homologous gene in humans is FAM132B and the sequence is conserved in other species. The protein is synthesized by erythroblasts and secreted. This sequence had previously been found expressed in mouse skeletal muscle, called myonectin (CTRP15), and linked to lipid homeostasis.
Excerpted from Wikipedia’s “Erythroferrone” article, available under the CC BY-SA 4.0 licence.