EXOSC3
Sign in to saveAlso known as PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10, CGI-102, Exosome component 3
protein-coding gene in the species Homo sapiens
Gene data
EXOSC3- Name
- exosome component 3
- Type
- protein-coding
- Position
- 37,759,234–37,832,117 (−)
- Aliases
- CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10
- Ensembl
- ENSG00000107371
- RefSeq RNA
- NM_001002269.2, NM_016042.4
- RefSeq protein
- NP_001002269.1, NP_057126.2
This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
Pathways
RNA degradation - Homo sapiens (human)Adaptive Immune SystemImmune SystemCellular responses to stressATF4 activates genes in response to endoplasmic reticulum stressPERK regulates gene expressionUnfolded Protein Response (UPR)Deadenylation-dependent mRNA decaymRNA decay by 3' to 5' exoribonucleaseButyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
via MyGene.info
Gene · Ensembl
exosome component 3
- Symbol
- EXOSC3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:37,759,234-37,832,117
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI