FASTKD3

Also known as FAST kinase domains 3

FAST kinase domain-containing protein 3 (FASTKD3) is a protein that in humans is encoded by the FASTKD3 gene on chromosome 5. This protein is part of the Fas-activated serine/threonine kinase domain (FASTKD) containing protein family, which is known for regulating the energy balance of mitochondria under stress.

Gene data

FASTKD3

Name: FAST kinase domains 3
Type: protein-coding
Position: 7,859,159–7,869,055 (−)
Ensembl: ENSG00000124279
RefSeq RNA: NM_024091.4, NR_036553.2, NR_073608.2, XM_006714498.2, XM_047417699.1
RefSeq protein: NP_076996.2, XP_006714561.1, XP_047273655.1, XP_047273656.1, XP_054209414.1

This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].