FBXL5

Also known as FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

Gene data

FBXL5

Name: F-box and leucine rich repeat protein 5
Type: protein-coding
Position: 15,569,541–15,681,679 (−)
Aliases: CC2D2A-AS1, FBL4, FBL5, FLR1
Ensembl: ENSG00000118564
RefSeq RNA: NM_001193534.2, NM_001193535.2, NM_001443839.1, NM_001443840.1, NM_001443841.1
RefSeq protein: NP_001180463.1, NP_001180464.1, NP_001430768.1, NP_001430769.1, NP_001430770.1

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010].

Gene Ontology

Biological process

intracellular iron ion homeostasis intracellular iron ion homeostasis intracellular iron ion homeostasis intracellular iron ion homeostasis protein ubiquitination protein ubiquitination protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Molecular function

ubiquitin-protein transferase activity iron ion binding protein binding

Cellular component

ubiquitin ligase complex nucleus nucleus cytosol SCF ubiquitin ligase complex SCF ubiquitin ligase complex SCF ubiquitin ligase complex perinuclear region of cytoplasm

Pathways

Adaptive Immune System Immune System Transport of small molecules Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Protein folding Metabolism of proteins Metabolism of proteins Post-translational protein modification Neddylation

via MyGene.info

Gene · Ensembl

F-box and leucine rich repeat protein 5

Symbol: FBXL5
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:15,569,541-15,681,679
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

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Encyclopedic overview

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Contents

References
Further reading

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.

Excerpted from Wikipedia’s “FBXL5” article, available under the CC BY-SA 4.0 licence.

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HECT and RLD domain containing E3 ubiquitin protein ligase 2

Protein

SMAD specific E3 ubiquitin protein ligase 1

Protein

F-box protein

Entity

iron-responsive element-binding protein

Entity