FBXL7

Also known as FBL6, FBL7, F-box and leucine-rich repeat protein 7, F-box and leucine rich repeat protein 7

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

Gene data

FBXL7

Name: F-box and leucine rich repeat protein 7
Type: protein-coding
Position: 15,500,140–15,939,795 (+)
Aliases: FBL6, FBL7
Ensembl: ENSG00000183580
RefSeq RNA: NM_001278317.2, NM_012304.5, XM_011513998.2, XM_017009262.3, XM_047417000.1
RefSeq protein: NP_001265246.1, NP_036436.1, XP_011512300.1, XP_016864751.1, XP_047272956.1

This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].

Gene Ontology

Biological process

G2/M transition of mitotic cell cycle G2/M transition of mitotic cell cycle protein polyubiquitination protein polyubiquitination protein polyubiquitination mitotic cell cycle mitotic cell cycle ubiquitin-dependent protein catabolic process

Molecular function

protein binding

Cellular component

ubiquitin ligase complex centrosome centrosome cytosol SCF ubiquitin ligase complex SCF ubiquitin ligase complex SCF ubiquitin ligase complex SCF ubiquitin ligase complex

Pathways

Adaptive Immune System Cell Cycle Immune System Metabolism of proteins Mitotic G2-G2/M phases Post-translational protein modification G2/M Transition Cell Cycle, Mitotic FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation

via MyGene.info

Gene · Ensembl

F-box and leucine rich repeat protein 7

Symbol: FBXL7
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:15,500,140-15,939,795
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 69121
exact match: identifiers.org/ncbigene/23194
genomic end: 15939900
genomic start: 15500180
cytogenetic location: 5p15.1

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F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.