FBXW5

Also known as Fbw5, F-box and WD repeat domain containing 5

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

Gene data

FBXW5

Name: F-box and WD repeat domain containing 5
Type: protein-coding
Aliases: Fbw5

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

F-box and WD repeat domain containing 5

Symbol: FBXW5
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:136,938,431-136,950,122
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8496
exact match: identifiers.org/ncbigene/54461
genomic end: 136944738
genomic start: 139834887
cytogenetic location: 9q34.3

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F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented. Well established targets of FBXW5 include TSC2 and SEC23B.