FCRLA
Sign in to saveAlso known as FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd
Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.
Gene data
FCRLA- Name
- Fc receptor like A
- Type
- protein-coding
- Position
- 161,706,958–161,714,352 (+)
- Aliases
- FCRL, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB
- Ensembl
- ENSG00000132185
- RefSeq RNA
- NM_001184866.2, NM_001184867.2, NM_001184870.2, NM_001184871.2, NM_001184872.2
- RefSeq protein
- NP_001171795.2, NP_001171796.2, NP_001171799.2, NP_001171800.2, NP_001171801.2
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
Fc receptor like A
- Symbol
- FCRLA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:161,706,958-161,714,352
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 13106
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/84824
- genomic end
- 161684142
- genomic start
- 161676762
- chromosome
- human chromosome 1
- cytogenetic location
- 1q23.3
- expressed in
- blood
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.
Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM]
Excerpted from Wikipedia’s “FCRLA” article, available under the CC BY-SA 4.0 licence.