FLRT3

Also known as HH21, fibronectin leucine rich transmembrane protein 3

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

Gene data

FLRT3

Name: fibronectin leucine rich transmembrane protein 3
Type: protein-coding
Position: 14,322,538–14,337,643 (−)
Aliases: HH21
Ensembl: ENSG00000125848
RefSeq RNA: NM_013281.4, NM_198391.3, XM_005260682.5, XM_011529204.3, XM_011529205.3
RefSeq protein: NP_037413.1, NP_938205.1, XP_005260739.1, XP_011527506.1, XP_011527507.1

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010].

Pathways

Developmental Biology Signal Transduction Signaling by FGFR Signaling by ROBO receptors Axon guidance Downstream signaling of activated FGFR1 Signaling by FGFR1 Signaling by Receptor Tyrosine Kinases Nervous system development

via MyGene.info

Gene · Ensembl

fibronectin leucine rich transmembrane protein 3

Symbol: FLRT3
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:14,322,538-14,337,643
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 8322
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23767
genomic end: 14337614
genomic start: 14322985
expressed in: hair follicle
chromosome: human chromosome 20
cytogenetic location: 20p12.1

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Excerpted from Wikipedia’s “FLRT3” article, available under the CC BY-SA 4.0 licence.