FREM2
Sign in to saveAlso known as FRAS1 related extracellular matrix protein 2, FRASRS2, FRAS1 related extracellular matrix 2, CRYPTOP
FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.
Gene data
FREM2- Name
- FRAS1 related extracellular matrix 2
- Type
- protein-coding
- Position
- 38,687,070–38,887,131 (+)
- Aliases
- CRYPTOP, FRASRS2
- Ensembl
- ENSG00000150893
- RefSeq RNA
- NM_207361.6, XM_017020554.2, XM_054374491.1, XR_008488759.1, XR_941571.3
- RefSeq protein
- NP_997244.4, XP_016876043.1, XP_054230466.1
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
FRAS1 related extracellular matrix 2
- Symbol
- FREM2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:38,687,070-38,887,131
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.
Excerpted from Wikipedia’s “FREM2” article, available under the CC BY-SA 4.0 licence.