GADD45G
Sign in to saveAlso known as CR6, DDIT2, GADD45gamma, GRP17, growth arrest and DNA damage inducible gamma
Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on chromosome 9. GADD45G is also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma. GADD45G is involved in several different processes, including sexual development, human-specific brain development, tumor suppression, and the cellular stress response. GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence. Low expression of GADD45G has been associated with many types of cancer.
Gene data
GADD45G- Name
- growth arrest and DNA damage inducible gamma
- Type
- protein-coding
- Position
- 89,604,939–89,609,775 (+)
- Aliases
- CR6, DDIT2, GADD45gamma, GRP17
- Ensembl
- ENSG00000130222
- RefSeq RNA
- NM_006705.4, XM_011518163.3, XM_054361814.1
- RefSeq protein
- NP_006696.1, XP_011516465.1, XP_054217789.1
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
growth arrest and DNA damage inducible gamma
- Symbol
- GADD45G
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:89,604,939-89,609,775
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~8 min read
Encyclopedic overview
9 sectionsContents
- History
- Structure and function
- Memory
- Interactions
- Tissue distribution
- Clinical significance
- See also
- References
- Further reading
Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on chromosome 9. GADD45G is also known as CR6, DDIT2, GRP17, OIG37, and GADD45gamma. GADD45G is involved in several different processes, including sexual development, human-specific brain development, tumor suppression, and the cellular stress response. GADD45G interacts with several other proteins that are involved in DNA repair, cell cycle control, apoptosis, and senescence. Low expression of GADD45G has been associated with many types of cancer.
== History ==
Excerpted from Wikipedia’s “GADD45G” article, available under the CC BY-SA 4.0 licence.