Person · Open Library
- Works
- 1
Top works
- The molecular genetic analysis of symbiotic nitrogen fixation (nif) genes from Rhizobium meliloti
via Open Library + Wikidata
Recent publications · Crossref
5 total works indexed
- The Measurement of Observer Agreement for Categorical Data
· 1977 · cited 61,628x
- <i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution
· 2010 · cited 23,303x
- Dynamic capabilities and strategic management
· 1997 · cited 19,798x
- <i>MolProbity</i>: all-atom structure validation for macromolecular crystallography
· 2009 · cited 13,675x
- WebLogo: A Sequence Logo Generator: Figure 1
· 2004 · cited 11,726x
via Crossref · CC0
Key facts
- Born
- Gary Bruce Ruvkun , ( 1952-03-26 ) March 26, 1952 (age 74) , Berkeley, California , U.S.
- Education
- University of California, Berkeley ( BA ), Harvard University ( PhD )
- Awards
- Wolf Prize in Medicine (2014) Nobel Prize in Physiology or Medicine (2024)
- Institutions
- University of California, Berkeley , Harvard University , Massachusetts Institute of Technology , Massachusetts General Hospital
- Thesis
- The Molecular Genetic Analysis of Symbiotic Nitrogen Fixation (NIF) Genes from Rhizobium Meliloti (1982)
- Doctoral advisor
- Frederick Ausubel
- Website
- Official website
via Wikipedia infobox
Article
Gary Bruce Ruvkun (born March 26, 1952) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston.
Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.
Gallery (2)
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Categories
1952 birthsAmerican geneticistsAmerican Nobel laureatesBenjamin Franklin Medal (Franklin Institute) laureatesBiogerontologistsHarvard Medical School alumniHarvard Medical School facultyJewish American scientistsJewish Nobel laureatesLiving peopleMassry Prize recipientsMembers of the American Philosophical Society