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Gary Ruvkun

File:Gary_Ruvkun,_2024_Nobel_Prize_Laureate_in_Medicine_3_(cropped).jpg · Wikimedia Commons · See Wikimedia Commons

EntityQ504021· pop 51· linked from 453 articles

Gary Ruvkun

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Also known as Gary Bruce Ruvkun, Gary B. Ruvkun

American geneticist

Person · Open Library

Works
1

Top works

  • The molecular genetic analysis of symbiotic nitrogen fixation (nif) genes from Rhizobium meliloti

via Open Library + Wikidata

Music · MusicBrainz

Type
Person
Gender
Male
Origin
United Kingdom
Active from
1958-03-08
dark waveelectronicelectronic rockelectronicagothic rockindustrial

Discography

Official siteDiscogsStream

via MusicBrainz · CC0

Recent publications · Crossref

5 total works indexed

  1. The Measurement of Observer Agreement for Categorical Data

    · 1977 · cited 63,319x

  2. <i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution

    · 2010 · cited 23,560x

  3. Dynamic capabilities and strategic management

    · 1997 · cited 19,798x

  4. <i>MolProbity</i>: all-atom structure validation for macromolecular crystallography

    · 2009 · cited 13,849x

  5. WebLogo: A Sequence Logo Generator: Figure 1

    · 2004 · cited 11,863x

via Crossref · CC0

Key facts

Born
Gary Bruce Ruvkun , ( 1952-03-26 ) March 26, 1952 (age 74) , Berkeley, California , U.S.
Education
University of California, Berkeley ( BA ), Harvard University ( PhD )
Awards
Wolf Prize in Medicine (2014) Nobel Prize in Physiology or Medicine (2024)
Institutions
University of California, Berkeley , Harvard University , Massachusetts Institute of Technology , Massachusetts General Hospital
Thesis
The Molecular Genetic Analysis of Symbiotic Nitrogen Fixation (NIF) Genes from Rhizobium Meliloti (1982)
Doctoral advisor
Frederick Ausubel
Website
Official website

via Wikipedia infobox

Nobel Prize

  • The Nobel Prize in Physiology or Medicine2024

    “for the discovery of microRNA and its role in post-transcriptional gene regulation”

    Shared · 1/2 portion

NobelPrize.org →

~10 min read

Encyclopedic overview

Gary Bruce Ruvkun (born March 26, 1952) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston.

Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.

Excerpted from Wikipedia’s “Gary Ruvkun” article, available under the CC BY-SA 4.0 licence.

Gallery (2)

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