gastrinoma
Sign in to saveAlso known as Gastrin Secreting tumor, Gastrin cell tumour, malignant gastrinoma, Gastrin-Producing Neuroendocrine Tumor, Gastrin-Producing NET, G-Cell Gastrin Producing Tumor, G-Cell Tumor
Gastrinomas are neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as Zollinger–Ellison syndrome (ZES). A large number of gastrinomas develop in the pancreas or duodenum, with near-equal frequency, and approximately 10% arise as primary neoplasms in lymph nodes of the pancreaticoduodenal region (gastrinoma triangle).
Key facts
- Medical condition (new).name
- Gastrinoma
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- Gastric_neuroendocrine_tumour_-_intermed_mag.jpg
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- 200
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- Micrograph of a neuroendocrine tumour of the stomach. H&E stain.
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- General surgery
via Wikipedia infobox
Research
2,142 papers- Gastrinoma.Current treatment options in oncology · 2001
- Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.World journal of gastroenterology · 2021
- All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.Journal of neuroendocrinology · 2023
- Gastrinoma.Cancer treatment and research · 2010
- Gastrinoma--morphological aspects.Wiener klinische Wochenschrift · 2007
via PubMed
~8 min read
Encyclopedic overview
10 sectionsContents
- Signs and symptoms
- Pathophysiology
- Diagnosis
- Treatment
- Prognosis
- Epidemiology
- Research
- See also
- References
- External links
Gastrinomas are neuroendocrine tumors (NETs), usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as Zollinger–Ellison syndrome (ZES). A large number of gastrinomas develop in the pancreas or duodenum, with near-equal frequency, and approximately 10% arise as primary neoplasms in lymph nodes of the pancreaticoduodenal region (gastrinoma triangle).
Most gastrinomas are sporadic (75–80%), whereas approximately 20–25% are associated with multiple endocrine neoplasia type 1 (MEN-1). Over 50% of gastrinomas are malignant and can metastasize to regional lymph nodes and liver. One fourth of gastrinomas are related to multiple endocrine neoplasia type 1, Zollinger–Ellison syndrome, peptic ulcer disease.
Excerpted from Wikipedia’s “gastrinoma” article, available under the CC BY-SA 4.0 licence.