Also known as GCL, grancalcin
Grancalcin is a protein that in humans is encoded by the GCA gene.
Gene data
GCA- Name
- grancalcin
- Type
- protein-coding
- Aliases
- GCL
This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016].
via MyGene.info
Gene · Ensembl
grancalcin
- Symbol
- GCA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:162,318,839-162,388,536
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Grancalcin is a protein that in humans is encoded by the GCA gene.
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
Excerpted from Wikipedia’s “GCA” article, available under the CC BY-SA 4.0 licence.