GCC2

Also known as GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.

Gene data

GCC2

Name: GRIP and coiled-coil domain containing 2
Type: protein-coding
Position: 108,449,107–108,509,415 (+)
Aliases: GCC185, RANBP2L4, REN53
Ensembl: ENSG00000135968
RefSeq RNA: NM_001410194.1, NM_181453.4, XM_006712870.4, XM_006712871.2, XM_006712872.4
RefSeq protein: NP_001397123.1, NP_852118.2, XP_006712933.1, XP_006712934.1, XP_006712935.1

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009].

Gene Ontology

Biological process

protein targeting to lysosome microtubule organizing center organization protein localization to Golgi apparatus microtubule anchoring late endosome to Golgi transport late endosome to Golgi transport retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport

Molecular function

protein binding small GTPase binding identical protein binding

Cellular component

nucleoplasm cytoplasm Golgi apparatus Golgi apparatus trans-Golgi network trans-Golgi network cytosol membrane

Pathways

Salmonella infection - Homo sapiens (human)Disease Membrane Trafficking Vesicle-mediated transport Diseases of signal transduction by growth factor receptors and second messengers Retrograde transport at the Trans-Golgi-Network Intra-Golgi and retrograde Golgi-to-ER traffic Signaling by ALK in cancer Signaling by ALK fusions and activated point mutants Deregulation of Rab and Rab Effector Genes in Bladder Cancer

via MyGene.info

Gene · Ensembl

GRIP and coiled-coil domain containing 2

Symbol: GCC2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:108,449,107-108,509,415
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

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found in taxon: Homo sapiens
HomoloGene ID: 45639
exact match: identifiers.org/ncbigene/9648
genomic end: 109125871
genomic start: 108449107
chromosome: human chromosome 2
cytogenetic location: 2q12.3

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Encyclopedic overview

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References
Further reading

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Excerpted from Wikipedia’s “GCC2” article, available under the CC BY-SA 4.0 licence.

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