geranyltranstransferase
Sign in to saveAlso known as farnesylpyrophosphate synthetase, farnesyl-diphosphate synthase, farnesyl diphosphate synthetase, farnesyl pyrophosphate synthetase, FPP synthetase, geranyltransferase, geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
In enzymology, a geranyltranstransferase () is an enzyme that catalyzes the chemical reaction
Research
608 papers- Polyprenyl diphosphate synthases.Sub-cellular biochemistry · 1997
- FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells.The journal of gene medicine · 2025
- Isoprenoid antibiotics.Biotechnology (Reading, Mass.) · 1995
- Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.Bioorganic & medicinal chemistry letters · 2021
- A non-natural biosynthesis pathway toward 2-methylisoborneol.Chemical communications (Cambridge, England) · 2022
via PubMed
Wikidata facts
- Subclass of
- transferase
Show 1 more fact
- EC enzyme number
- 2.5.1.10
Sources (1)
via Wikidata · CC0
~6 min read
Encyclopedic overview
6 sectionsContents
- Nomenclature
- Structure
- Mechanism
- Function
- Drug targeting
- References
In enzymology, a geranyltranstransferase () is an enzyme that catalyzes the chemical reaction geranyl diphosphate + isopentenyl diphosphate \rightleftharpoons diphosphate + trans,trans-farnesyl diphosphate
Thus, the two substrates of this enzyme are geranyl diphosphate (a 10 carbon precursor) and isopentenyl diphosphate (a 5 carbon precursor) whereas its two products are diphosphate and trans,trans-farnesyl diphosphate (a 15 carbon product).
Excerpted from Wikipedia’s “geranyltranstransferase” article, available under the CC BY-SA 4.0 licence.