glucagonoma
Sign in to saveGlucagonoma is a very rare tumor of the alpha cells of the pancreas that results in the overproduction of the hormone glucagon. Typically associated with a rash called necrolytic migratory erythema, weight loss, and mild diabetes mellitus, most people with glucagonoma contract it spontaneously. However, about 10% of cases are associated with multiple endocrine neoplasia type 1 (MEN-1) syndrome.
Key facts
- Medical condition (new).name
- Glucagonoma
- Medical condition (new).caption
- Skin changes associated with Glucagonoma
- Medical condition (new).field
- Oncology
via Wikipedia infobox
Research
1,280 papers- Glucagonoma and Glucagonoma Syndrome: An Updated Review.Clinical endocrinology · 2025
- Genetic disorders and insulinoma/glucagonoma.Endocrine-related cancer · 2024
- Glucagonoma syndrome.The American journal of medicine · 1987
- Synchronous Insulinoma and Glucagonoma: A Review of the Literature.In vivo (Athens, Greece) · 2023
- Glucagonoma and pseudoglucagonoma syndromes.International journal of dermatology · 1997
via PubMed
~4 min read
Encyclopedic overview
7 sectionsContents
- Causes
- Mechanism
- Diagnosis
- Treatment
- History
- References
- External links
Glucagonoma is a very rare tumor of the alpha cells of the pancreas that results in the overproduction of the hormone glucagon. Typically associated with a rash called necrolytic migratory erythema, weight loss, and mild diabetes mellitus, most people with glucagonoma contract it spontaneously. However, about 10% of cases are associated with multiple endocrine neoplasia type 1 (MEN-1) syndrome.
== Causes == Although the cause of glucagonoma is unknown, some genetic factors may lead to the condition. A family history of multiple endocrine neoplasia type 1 (MEN1) is a risk factor. Additionally, those with Mahvash disease have an increased risk for glucagonoma, as the glucagon receptor gene (GCGR) is mutated.
Excerpted from Wikipedia’s “glucagonoma” article, available under the CC BY-SA 4.0 licence.