GMEB1

Also known as P96PIF, PIF96, glucocorticoid modulatory element binding protein 1

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.

Gene data

GMEB1

Name: glucocorticoid modulatory element binding protein 1
Type: protein-coding
Position: 28,668,280–28,719,353 (+)
Aliases: P96PIF, PIF96
Ensembl: ENSG00000162419
RefSeq RNA: NM_001319674.2, NM_006582.4, NM_024482.3, XM_011540518.3, XM_011540519.3
RefSeq protein: NP_001306603.1, NP_006573.2, NP_077808.1, XP_011538820.1, XP_011538821.1

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016].

Gene Ontology

Biological process

negative regulation of apoptotic process positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm

via MyGene.info

Gene · Ensembl

glucocorticoid modulatory element binding protein 1

Symbol: GMEB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:28,668,280-28,719,353
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein GMEB1 PDB 1oqj.png

Show 8 more facts

HomoloGene ID: 10647
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10691
genomic end: 29045865
genomic start: 28668778
chromosome: human chromosome 1
cytogenetic location: 1p35.3
expressed in: amniotic fluid

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.

== Function ==

Excerpted from Wikipedia’s “GMEB1” article, available under the CC BY-SA 4.0 licence.

Available in 6 languages

via Wikidata sitelinks · CC0