GPRASP1

Also known as GASP, GASP-1, GASP1, G protein-coupled receptor associated sorting protein 1

G-protein coupled receptor-associated sorting protein 1 is a protein that in humans is encoded by the GPRASP1 gene.

Gene data

GPRASP1

Name: G protein-coupled receptor associated sorting protein 1
Type: protein-coding
Chromosome: X
Position: 102,650,345–102,659,083 (+)
Aliases: GASP, GASP-1, GASP1
Ensembl: ENSG00000198932
RefSeq RNA: NM_001099410.2, NM_001099411.2, NM_001184727.2, NM_014710.5
RefSeq protein: NP_001092880.1, NP_001092881.1, NP_001171656.1, NP_055525.3

This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010].