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GeneQ18026610· pop 5· linked from 5 articles

GTF2A1

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Also known as TF2A1, TFIIA, TFIIA-42, TFIIAL, general transcription factor IIA subunit 1

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

Gene data

GTF2A1

Name: general transcription factor IIA subunit 1
Type: protein-coding
Position: 81,175,452–81,221,377 (−)
Aliases: TF2A1, TFIIA, TFIIA-42, TFIIAL
Ensembl: ENSG00000165417
RefSeq RNA: NM_001278940.2, NM_015859.4, NM_201595.3
RefSeq protein: NP_001265869.1, NP_056943.1, NP_963889.1

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010].

Gene Ontology

Biological process

transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter transcription initiation at RNA polymerase II promoter positive regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly positive regulation of transcription initiation by RNA polymerase II

Molecular function

RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II general transcription initiation factor binding DNA binding transcription coregulator activity protein binding RNA polymerase II general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity

Cellular component

nucleus nucleus nucleoplasm nucleoplasm nucleoplasm transcription factor TFIID complex transcription factor TFIID complex transcription factor TFIIA complex

Pathways

Basal transcription factors - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Signal Transduction HIV Life Cycle Late Phase of HIV Life Cycle HIV Infection Disease HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome

via MyGene.info

Gene · Ensembl

general transcription factor IIA subunit 1

Symbol: GTF2A1
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:81,175,452-81,221,377
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein GTF2A1 PDB 1nvp.png

Show 5 more facts

HomoloGene ID: 56331
exact match: identifiers.org/ncbigene/2957
genomic end: 81687721
genomic start: 81641796
cytogenetic location: 14q31.1

Sources (4)

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Article

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Further reading

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

== Interactions ==

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Categories

Genes on human chromosome 14 Transcription factors