GTPBP4
Sign in to saveAlso known as CRFG, NGB, NOG1, GTP binding protein 4
Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.
Gene data
GTPBP4- Name
- GTP binding protein 4
- Type
- protein-coding
- Position
- 988,409–1,020,001 (+)
- Aliases
- CRFG, NGB, NOG1
- Ensembl
- ENSG00000107937
- RefSeq RNA
- NM_012341.3, XM_047424932.1, XM_054365374.1
- RefSeq protein
- NP_036473.2, XP_047280888.1, XP_054221349.1
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
GTP binding protein 4
- Symbol
- GTPBP4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:988,409-1,020,001
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7100
- expressed in
- gastrocnemius muscle
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23560
- genomic end
- 1019932
- genomic start
- 988434
- chromosome
- human chromosome 10
- cytogenetic location
- 10p15.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.
GTPases function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G protein-coupled receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
Excerpted from Wikipedia’s “GTPBP4” article, available under the CC BY-SA 4.0 licence.