GZMM
Sign in to saveAlso known as LMET1, MET1, granzyme M
Granzyme M is a protein that in humans is encoded by the GZMM gene.
Gene data
GZMM- Name
- granzyme M
- Type
- protein-coding
- Position
- 544,034–549,924 (+)
- Aliases
- LMET1, MET1
- Ensembl
- ENSG00000197540
- RefSeq RNA
- NM_001258351.2, NM_005317.4
- RefSeq protein
- NP_001245280.2, NP_005308.2
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
granzyme M
- Symbol
- GZMM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:544,034-549,924
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Granzyme M is a protein that in humans is encoded by the GZMM gene.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
Excerpted from Wikipedia’s “GZMM” article, available under the CC BY-SA 4.0 licence.