H1-1

Also known as H1.1, H1A, H1F1, HIST1, histone cluster 1, H1a, histone cluster 1 H1 family member a, H1.1 linker histone, cluster member, HIST1H1A

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.

In the Vinony graph

Within Vinony's link graph, H1-1 is referenced by 2 other articles, and connects out to Q180686, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Its subject is documented across 5 Wikipedia language editions.

Gene data

H1-1

Name: H1.1 linker histone, cluster member
Type: protein-coding
Position: 26,017,032–26,017,787 (−)
Aliases: H1.1, H1A, H1F1, HIST1, HIST1H1A
Ensembl: ENSG00000124610
RefSeq RNA: NM_005325.4
RefSeq protein: NP_005316.1

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].

Pathways

Apoptosis Apoptosis induced DNA fragmentation Cellular responses to stress Cellular Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF)DNA Damage/Telomere Stress Induced Senescence Programmed Cell Death Apoptotic execution phase Cellular responses to stimuli

via MyGene.info

Gene · Ensembl

H1.1 linker histone, cluster member

Symbol: H1-1
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:26,017,032-26,017,787
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Cryo-EM structure of BAF-Lamin AC IgF-H1-nucleosome complex - Histone H1.1 (2) 9J8O.png

Show 5 more facts

HomoloGene ID: 134658
exact match: identifiers.org/ncbigene/3024
genomic end: 26017787
genomic start: 26017032
cytogenetic location: 6p22.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

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Contents

References
Further reading

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Excerpted from Wikipedia’s “H1-1” article, available under the CC BY-SA 4.0 licence.