H1-3
Sign in to saveAlso known as H1.3, H1D, H1F3, H1s-2, histone cluster 1, H1d, histone cluster 1 H1 family member d, H1.3 linker histone, cluster member, HIST1H1D
Histone H1.3 is a protein encoded by the HIST1H1D gene in humans.
Gene data
H1-3- Name
- H1.3 linker histone, cluster member
- Type
- protein-coding
- Position
- 26,234,212–26,234,987 (−)
- Aliases
- H1.3, H1D, H1F3, H1s-2, HIST1H1D
- Ensembl
- ENSG00000124575
- RefSeq RNA
- NM_005320.3
- RefSeq protein
- NP_005311.1
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
H1.3 linker histone, cluster member
- Symbol
- H1-3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:26,234,212-26,234,987
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Histone H1.3 is a protein encoded by the HIST1H1D gene in humans.
Histones are basic nuclear proteins that play a crucial role in the nucleosome structure of chromosomal fibers in eukaryotes. Two molecules each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped to create repeating units called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and facilitates the compaction of chromatin into higher-order structures. This intronless gene encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails and instead contain a palindromic termination element. This gene is located within the large histone gene cluster on chromosome 6.
Excerpted from Wikipedia’s “H1-3” article, available under the CC BY-SA 4.0 licence.