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GeneQ18054954· pop 6· linked from 3 articles

H2AC21

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Also known as H2AB, histone cluster 2, H2ab, histone cluster 2 H2A family member b, H2A clustered histone 21, HIST2H2AB

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.

Gene data

H2AC21
Name
H2A clustered histone 21
Type
protein-coding
Position
149,887,469–149,887,965 (−)
Aliases
H2AB, HIST2H2AB
Ensembl
ENSG00000184270
RefSeq RNA
NM_175065.3
RefSeq protein
NP_778235.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015].

Gene Ontology

Biological process

heterochromatin formation

Pathways

Necroptosis - Homo sapiens (human)Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)DiseaseHDACs deacetylate histonesHATs acetylate histonesHATs acetylate histonesRMTs methylate histone argininesChromatin modifying enzymes

via MyGene.info

Gene · Ensembl

H2A clustered histone 21

Symbol
H2AC21
Biotype
Protein coding
Organism
Homo sapiens
Location
1:149,887,469-149,887,965
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Histone H2A type 2-B is a protein that in humans is encoded by the HIST2H2AB gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.

Excerpted from Wikipedia’s “H2AC21” article, available under the CC BY-SA 4.0 licence.

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