Halicin (SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes, but development was discontinued for this application due to poor results in testing. In 2019, this molecule was found by an artificial intelligence (AI) model to show antibiotic properties against a number of bacteria.
Halicin (SU-3327) is an experimental drug that acts as an enzyme inhibitor of c-Jun N-terminal kinase (JNK). Originally, it was researched for the treatment of diabetes, but development was discontinued for this application due to poor results in testing. In 2019, this molecule was found by an artificial intelligence (AI) model to show antibiotic properties against a number of bacteria.
==History== Halicin was previously known as SU-3327, developed by a group of researchers from Burnham Institute for Medical Research, United States in 2009 for investigations into diabetes treatment. Researchers named the molecule after the fictional artificial intelligence system Hal from 2001: A Space Odyssey.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).