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hematoporphyrin
Sign in to saveAlso known as 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-dipropanoic acid
Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900.
Chemical data
- Formula
- C34H38N4O6
- Molecular weight
- 598.7 g/mol
- IUPAC name
- 3-[18-(2-carboxyethyl)-8,13-bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid
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Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Has part
- carbon
- Mass
- 598.2791349360001
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- canonical SMILES
- O=C(O)CCC=5c2nc(cc4c(c(c(cc1c(c(c(n1)cc/3nc(c2)\C(=C\3C)CCC(=O)O)C(O)C)C)n4)C(O)C)C)C=5C
- chemical formula
- C₃₄H₃₈N₄O₆
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Encyclopedic overview
1 sectionsContents
- References
Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900.
It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy.
Excerpted from Wikipedia’s “hematoporphyrin” article, available under the CC BY-SA 4.0 licence.
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