HIF1AN
Sign in to saveAlso known as FIH1, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, HIFAN
Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.
Gene data
HIF1AN- Name
- hypoxia inducible factor 1 subunit alpha inhibitor
- Type
- protein-coding
- Position
- 100,529,072–100,681,896 (+)
- Aliases
- FIH1
- Ensembl
- ENSG00000166135
- RefSeq RNA
- NM_017902.3, XM_011539940.3, XM_054366249.1
- RefSeq protein
- NP_060372.2, XP_011538242.1, XP_054222224.1
Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
hypoxia inducible factor 1 subunit alpha inhibitor
- Symbol
- HIF1AN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:100,529,072-100,681,896
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HIF1AN PDB 1h2k.png
Show 8 more facts
- HomoloGene ID
- 9906
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/55662
- genomic end
- 102319755
- genomic start
- 102288829
- chromosome
- human chromosome 10
- cytogenetic location
- 10q24.31
- expressed in
- islet of Langerhans
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Hypoxia-inducible factor 1-alpha inhibitor (FIH) is a protein that in humans is encoded by the HIF1AN gene.
== Interactions ==
Excerpted from Wikipedia’s “HIF1AN” article, available under the CC BY-SA 4.0 licence.