HIRIP3
Sign in to saveAlso known as HIRA interacting protein 3
HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.
Gene data
HIRIP3- Name
- HIRA interacting protein 3
- Type
- protein-coding
- Position
- 29,992,314–29,996,126 (−)
- Ensembl
- ENSG00000149929
- RefSeq RNA
- NM_001197323.1, NM_003609.5
- RefSeq protein
- NP_001184252.1, NP_003600.2
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
HIRA interacting protein 3
- Symbol
- HIRIP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:29,992,314-29,996,126
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a protein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.
Excerpted from Wikipedia’s “HIRIP3” article, available under the CC BY-SA 4.0 licence.