HNRNPH1
Sign in to saveAlso known as HNRPH, HNRPH1, hnRNPH, heterogeneous nuclear ribonucleoprotein H1 (H), heterogeneous nuclear ribonucleoprotein H1
Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.
Gene data
HNRNPH1- Name
- heterogeneous nuclear ribonucleoprotein H1
- Type
- protein-coding
- Position
- 179,614,170–179,634,784 (−)
- Aliases
- HNRPH, HNRPH1, NEDCDS, hnRNPH
- Ensembl
- ENSG00000284254
- RefSeq RNA
- NM_001257293.2, NM_001363572.2, NM_001364225.2, NM_001364226.2, NM_001364227.2
- RefSeq protein
- NP_001244222.1, NP_001350501.1, NP_001351154.1, NP_001351155.1, NP_001351156.1
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
heterogeneous nuclear ribonucleoprotein H1
- Symbol
- HNRNPH1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:179,614,170-179,634,784
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties; The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs, making it very similar to the family member HNRPF in that regard. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.
Excerpted from Wikipedia’s “HNRNPH1” article, available under the CC BY-SA 4.0 licence.