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GeneQ18038239· pop 5· linked from 11 articles

HSPB8

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Also known as CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22, heat shock protein family B (small) member 8

Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene.

Gene data

HSPB8
Name
heat shock protein family B (small) member 8
Type
protein-coding
Position
119,171,555–119,224,855 (+)
Aliases
CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HMND2, HSP22, HSPB8-N1, HSPB8-N2
Ensembl
ENSG00000152137
RefSeq RNA
NM_014365.3
RefSeq protein
NP_055180.1

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Cellular responses to stressCellular response to heat stressHSF1-dependent transactivationCellular responses to stimuliIL-18 signaling pathwayIntracellular trafficking proteins involved in CMT neuropathy

via MyGene.info

Gene · Ensembl

heat shock protein family B (small) member 8

Symbol
HSPB8
Biotype
Protein coding
Organism
Homo sapiens
Location
12:119,171,555-119,224,855
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
8654
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/26353
genomic end
119224855
genomic start
119171555
chromosome
human chromosome 12
cytogenetic location
12q24.23
Commons category
HSPB8
Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections
Contents
  • Interactions
  • Clinical importance
  • References
  • Further reading
  • External links

Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene.

== Interactions ==

Excerpted from Wikipedia’s “HSPB8” article, available under the CC BY-SA 4.0 licence.

Available in 4 languages

via Wikidata sitelinks · CC0