Hyaluronan binding protein 2
Sign in to saveAlso known as hepatocyte growth factor activator-like protein, factor VII-activating protease, Plasma hyaluronan-binding protein, hyaluronan-binding protein 2, hyaluronic acid binding protein 2, factor VII activating protein, factor seven-activating protease, plasma hyaluronan binding protein
Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.
Protein · UniProt
Factor VII-activating protease
- Gene
- HABP2
- Organism
- Homo sapiens (Human)
- Length
- 560 aa
- Molecular mass
- 62,672 Da
- Evidence
- 1: Evidence at protein level
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell m…
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 4 more facts
- P352
- Narcea River
- biological process
- proteolysis
- cell component
- extracellular space
- found in taxon
- Homo sapiens
Sources (4)
via Wikidata · CC0
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Encyclopedic overview
2 sectionsContents
- References
- Further reading
Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.
The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.
Excerpted from Wikipedia’s “Hyaluronan binding protein 2” article, available under the CC BY-SA 4.0 licence.