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IL-18, IL 18 or IL18 may refer to: Interleukin 18, a protein encoded in humans by the IL18 gene Ilyushin Il-18 (1957), a Cold War–era Soviet turboprop airliner and military transport Ilyushin Il-18 (1946), a prototype Soviet radial-engined airliner Illinois's 18th congressional district, a defunct U.S. House district Illinois Route 18, a rural east–west state road in central Illinois, U.S.
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