IL31RA
Sign in to saveAlso known as CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384
Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.
Gene data
IL31RA- Name
- interleukin 31 receptor A
- Type
- protein-coding
- Position
- 55,851,357–55,922,854 (+)
- Aliases
- CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R, zcytoR17
- Ensembl
- ENSG00000164509
- RefSeq RNA
- NM_001242636.2, NM_001242637.2, NM_001242638.2, NM_001242639.2, NM_001297570.3
- RefSeq protein
- NP_001229565.1, NP_001229566.1, NP_001229567.1, NP_001229568.1, NP_001284499.1
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
interleukin 31 receptor A
- Symbol
- IL31RA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:55,851,357-55,922,854
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 51395
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/133396
- genomic end
- 55922854
- genomic start
- 55851357
- chromosome
- human chromosome 5
- cytogenetic location
- 5q11.2
- expressed in
- tibia
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene.
IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004).[supplied by OMIM]
Excerpted from Wikipedia’s “IL31RA” article, available under the CC BY-SA 4.0 licence.