IMPDH1
Sign in to saveAlso known as IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608, IMP (inosine 5'-monophosphate) dehydrogenase 1, inosine monophosphate dehydrogenase 1
Gen der Spezies Homo sapiens
Gene data
IMPDH1- Name
- inosine monophosphate dehydrogenase 1
- Type
- protein-coding
- Position
- 128,392,277–128,410,009 (−)
- Aliases
- IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
- Ensembl
- ENSG00000106348
- RefSeq RNA
- NM_000883.4, NM_001102605.2, NM_001142573.2, NM_001142574.2, NM_001142575.2
- RefSeq protein
- NP_000874.2, NP_001096075.1, NP_001136045.1, NP_001136046.1, NP_001136047.1
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
inosine monophosphate dehydrogenase 1
- Symbol
- IMPDH1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:128,392,277-128,410,009
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- PDB 1jcn EBI.jpg
Show 7 more facts
- HomoloGene ID
- 68096
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3614
- chromosome
- human chromosome 7
- genomic start
- 128032331
- genomic end
- 128050306
- cytogenetic location
- 7q32.1
Sources (3)
via Wikidata · CC0