Interleukin 23 subunit alpha

Also known as IL-23-A, IL-23p19, IL23A, interleukin 23 p19 subunit, interleukin-23 subunit p19, IL-23 subunit alpha, interleukin 23, alpha subunit p19, JKA3 induced upon T-cell activation

mammalian protein found in Homo sapiens

Protein · UniProt

Interleukin-23 subunit alpha

Gene: IL23A
Organism: Homo sapiens (Human)
Length: 189 aa
Molecular mass: 20,730 Da
Evidence: 1: Evidence at protein level

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:29287995, PubMed:32474165, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production …

3D-structureAntiviral defenseCytokineDisulfide bondImmunityInflammatory responseInnate immunityProteomics identification

View on UniProt →

Swiss-Prot (reviewed) · via UniProt