Interstitial collagenase

Name

matrix metallopeptidase 1

Type

protein-coding

Position

102,789,401–102,798,167 (−)

Aliases

CLG

Ensembl

ENSG00000196611

RefSeq RNA

NM_001145938.2, NM_002421.4

RefSeq protein

NP_001139410.1, NP_002412.1

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].

via MyGene.info

Gene · Ensembl

matrix metallopeptidase 1

Symbol

MMP1

Biotype

Protein coding

Organism

Homo sapiens

Location

11:102,789,401-102,798,167

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein MMP1 PDB 1ayk.png

via Wikidata · CC0