INTS12

Also known as INT12, PHF22, SBBI22, integrator complex subunit 12

Gen der Spezies Homo sapiens

Gene data

INTS12

Name: integrator complex subunit 12
Type: protein-coding
Position: 105,682,014–105,895,986 (−)
Aliases: INT12, PHF22, SBBI22
Ensembl: ENSG00000138785
RefSeq RNA: NM_001142471.2, NM_020395.4, XM_005263148.6, XM_011532143.3, XM_011532145.3
RefSeq protein: NP_001135943.1, NP_065128.2, XP_005263205.1, XP_011530445.1, XP_011530447.1

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

snRNA processing snRNA processing snRNA processing regulation of transcription elongation by RNA polymerase II regulation of transcription elongation by RNA polymerase II snRNA 3'-end processing RNA polymerase II transcription initiation surveillance RNA polymerase II transcription initiation surveillance

Molecular function

protein binding

Cellular component

nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm nuclear body integrator complex

Pathways

RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription RNA Polymerase II Transcription Gene expression (Transcription)Gene expression (Transcription)

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human chromosome 4

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