irofulven
Sign in to saveAlso known as HMAF, 6-hydroxymethylacylfulvene
Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF and MGI-114) is an experimental cancer drug. It belongs to the family of drugs called alkylating agents.
Research
119 papers- Morning for Irofulven, What Could be fiNER?Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
- Irofulven (MGI Pharma).Current opinion in investigational drugs (London, England : 2000) · 2002
- Irofulven induces replication-dependent CHK2 activation related to p53 status.Biochemical pharmacology · 2007
- Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting.Ageing research reviews · 2025
- Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells.Cancer chemotherapy and pharmacology · 2006
via PubMed
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Encyclopedic overview
4 sectionsContents
- Licensing and Clinical development
- Synthesis
- Mechanism
- References
Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF and MGI-114) is an experimental cancer drug. It belongs to the family of drugs called alkylating agents.
It inhibits the DNA replication of cultured cells deficient in the nucleotide excision repair pathway.
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