ITGB1BP1
Sign in to saveAlso known as ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B, integrin subunit beta 1 binding protein 1
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.
Gene data
ITGB1BP1- Name
- integrin subunit beta 1 binding protein 1
- Type
- protein-coding
- Position
- 9,402,707–9,423,891 (−)
- Aliases
- ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B
- Ensembl
- ENSG00000119185
- RefSeq RNA
- NM_001319066.2, NM_001319067.2, NM_001319068.2, NM_001319069.2, NM_001319070.2
- RefSeq protein
- NP_001305995.1, NP_001305996.1, NP_001305997.1, NP_001305998.1, NP_001305999.1
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
integrin subunit beta 1 binding protein 1
- Symbol
- ITGB1BP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:9,402,707-9,423,891
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 3496
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9270
- genomic end
- 9423528
- genomic start
- 9543604
- chromosome
- human chromosome 2
- cytogenetic location
- 2p25.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.
Excerpted from Wikipedia’s “ITGB1BP1” article, available under the CC BY-SA 4.0 licence.