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Jules A. Hoffmann is a French biologist who made significant contributions to understanding how organisms defend themselves against infections. His research on the immune system mechanisms in fruit flies helped reveal fundamental principles of immunity that are relevant to human health and earned him international recognition in the scientific community.
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Person · Open Library
- Works
- 1
Top works
- Phylogenetic perspectives in immunity
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Music · MusicBrainz
- Type
- Person
- Gender
- Male
- Origin
- Germany
- Active from
- 1776-01-24
- Active to
- 1822-06-25
Discography
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Recent publications · Crossref
5 total works indexed
- The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
· 2021 · cited 77,697x
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
· 2020 · cited 17,306x
- Environmental Applications of Semiconductor Photocatalysis
· 1995 · cited 17,028x
- IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0–50,000 Years cal BP
· 2013 · cited 9,522x
- Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
· 2018 · cited 9,395x
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Described at
C.V. de Jules Hoffmann, Membre de l'Acad�mie des sciences
academie-sciences.fr →FERRANDON D, IMLER JL, HETRU C, HOFFMANN JA. The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections. Nature Reviews of Immunology (2007) 7, 862-874.
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Wikidata facts
- Official website
- www-ibmc.u-strasbg.fr/ridi/profil.php?equipe_id=10
- Image
- Nobel Prize 2011-Press Conference KI-DSC 7584.jpg
Show 5 more facts
- Commons category
- Jules Hoffmann
- date of birth
- 1941-08-02
- name in native language
- Jules Hoffmann
- described at URL
- www.academie-sciences.fr/pdf/membre/HoffmannJ_bio1009.pdf
- affiliation string
- University of Strasbourg
Sources (12)
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~7 min read
Article
Jules Alphonse Nicolas Hoffmann ( French pronunciation: [ʒyl ɔfman]; born 2 August 1941) is a Luxembourgish-French biologist. During his youth, growing up in Luxembourg, he developed a strong interest in insects under the influence of his father, Jos Hoffmann. This eventually resulted in the younger Hoffmann's dedication to the field of biology using insects as model organisms. He currently holds a faculty position at the University of Strasbourg. He is a research director and member of the board of administrators of the National Center of Scientific Research (CNRS) in Strasbourg, France. He was elected to the positions of Vice-President (2005–2006) and President (2007–2008) of the French Academy of Sciences. Hoffmann and Bruce Beutler were jointly awarded a half share of the 2011 Nobel Prize in Physiology or Medicine for "their discoveries concerning the activation of innate immunity".
Hoffmann and Bruno Lemaitre discovered the function of the fruit fly Toll gene in innate immunity. Its mammalian homologs, the Toll-like receptors, were discovered by Beutler. Toll-like receptors identify constituents of other organisms like fungi and bacteria, and trigger an immune response, explaining, for example, how septic shock can be triggered by bacterial remains.