KDM2A

Name

lysine demethylase 2A

Type

protein-coding

Position

67,119,247–67,258,082 (+)

Aliases

CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA

Ensembl

ENSG00000173120

RefSeq RNA

NM_001256405.2, NM_012308.3, NR_027473.2, XM_006718480.4, XM_011544861.2

RefSeq protein

NP_001243334.1, NP_036440.1, XP_006718543.1, XP_011543163.1, XP_016872880.1

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

via MyGene.info

Gene · Ensembl

lysine demethylase 2A

Symbol

KDM2A

Biotype

Protein coding

Organism

Homo sapiens

Location

11:67,119,247-67,258,082

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein FBXL11 PDB 2yu1.png

via Wikidata · CC0