KREMEN1
Sign in to saveAlso known as KREMEN, KRM1, kringle containing transmembrane protein 1, ECTD13
Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. Kremen1 is conserved in chordates including amphioxus and most vertebrate species. The protein is a type I transmembrane receptor of ligands Dickkopf1, Dickkopf2, Dickkopf3, Dickkopf4, EpCAM and Rspondin1.
Gene data
KREMEN1- Name
- kringle containing transmembrane protein 1
- Type
- protein-coding
- Position
- 29,072,937–29,168,333 (+)
- Aliases
- ECTD13, KREMEN, KRM1
- Ensembl
- ENSG00000183762
- RefSeq RNA
- NM_001039570.3, NM_032045.5, NM_153379.2, XM_011530429.3, XM_011530430.3
- RefSeq protein
- NP_001034659.2, NP_114434.3, XP_011528731.1, XP_011528732.1, XP_011528733.1
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
kringle containing transmembrane protein 1
- Symbol
- KREMEN1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:29,072,937-29,168,333
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. Kremen1 is conserved in chordates including amphioxus and most vertebrate species. The protein is a type I transmembrane receptor of ligands Dickkopf1, Dickkopf2, Dickkopf3, Dickkopf4, EpCAM and Rspondin1.
== Function == This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular Kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Excerpted from Wikipedia’s “KREMEN1” article, available under the CC BY-SA 4.0 licence.