L3MBTL1
Sign in to saveAlso known as H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3, l(3)mbt-like 1 (Drosophila), L3MBTL1, histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 1
Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.
Gene data
L3MBTL1- Name
- L3MBTL histone methyl-lysine binding protein 1
- Type
- protein-coding
- Position
- 43,489,442–43,550,954 (+)
- Aliases
- H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3
- Ensembl
- ENSG00000185513
- RefSeq RNA
- NM_001377303.1, NM_001377306.1, NM_001377307.1, NM_001377308.1, NM_001377309.1
- RefSeq protein
- NP_001364232.1, NP_001364235.1, NP_001364236.1, NP_001364237.1, NP_001364238.1
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
L3MBTL histone methyl-lysine binding protein 1
- Symbol
- L3MBTL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:43,489,442-43,550,954
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein L3MBTL PDB 1oyx.png
Show 8 more facts
- exact match
- identifiers.org/ncbigene/26013
- HomoloGene ID
- 41846
- found in taxon
- Homo sapiens
- genomic end
- 42179590
- genomic start
- 43489442
- chromosome
- human chromosome 20
- cytogenetic location
- 20q13.12
- expressed in
- glutes
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.
This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Excerpted from Wikipedia’s “L3MBTL1” article, available under the CC BY-SA 4.0 licence.