LCP1

Also known as CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, lymphocyte cytosolic protein 1

Plastin-2 is a protein that in humans is encoded by the LCP1 gene.

Gene data

LCP1

Name: lymphocyte cytosolic protein 1
Type: protein-coding
Position: 46,125,920–46,211,871 (−)
Aliases: CP64, HEL-S-37, L-PLASTIN, LC64P, PLS2
Ensembl: ENSG00000136167
RefSeq RNA: NM_002298.5, XM_005266374.3, XM_047430303.1, XM_047430304.1, XM_047430305.1
RefSeq protein: NP_002289.2, XP_005266431.1, XP_047286259.1, XP_047286260.1, XP_047286261.1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008].