LCTL
Sign in to saveAlso known as KLG, KLPH, lactase like
Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.
Gene data
LCTL- Name
- lactase like
- Type
- protein-coding
- Position
- 66,547,179–66,566,003 (−)
- Aliases
- KLG, KLPH
- Ensembl
- ENSG00000188501
- RefSeq RNA
- NM_001278562.3, NM_001394632.1, NM_001394633.1, NM_207338.4, NR_103739.3
- RefSeq protein
- NP_001265491.1, NP_001381561.1, NP_001381562.1, NP_997221.2
This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
lactase like
- Symbol
- LCTL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 15:66,547,179-66,566,003
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 70710
- exact match
- identifiers.org/ncbigene/197021
- chromosome
- human chromosome 15
- genomic start
- 66839517
- genomic end
- 66565998
- cytogenetic location
- 15q22.31
- found in taxon
- Homo sapiens
- expressed in
- putamen
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Lactase-like is a protein that in humans is encoded by the LCTL gene. Lactase-like is a glycosidase enzyme.
== Function == This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Excerpted from Wikipedia’s “LCTL” article, available under the CC BY-SA 4.0 licence.