LHX4

Also known as CPHD4, LIM homeobox 4

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.

Gene data

LHX4

Name: LIM homeobox 4
Type: protein-coding
Position: 180,228,787–180,278,984 (+)
Aliases: CPHD4
Ensembl: ENSG00000121454
RefSeq RNA: NM_033343.4, XM_011510105.3, XM_011510106.4, XM_011510108.3, XM_054339483.1
RefSeq protein: NP_203129.1, XP_011508407.1, XP_011508408.1, XP_011508410.1, XP_054195458.1

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II neuron differentiation positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding protein binding zinc ion binding

Cellular component

chromatin nucleus nucleus

Pathways

Developmental Biology Signaling by ROBO receptors Axon guidance Regulation of expression of SLITs and ROBOs Nervous system development

via MyGene.info

Gene · Ensembl

LIM homeobox 4

Symbol: LHX4
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:180,228,787-180,278,984
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 56497
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/89884
genomic end: 180278984
genomic start: 180230264
chromosome: human chromosome 1
cytogenetic location: 1q25.2

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Encyclopedic overview

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Contents

References
Further reading

LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.

Excerpted from Wikipedia’s “LHX4” article, available under the CC BY-SA 4.0 licence.

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