Lipstatin

Also known as L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester, L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadienyl ester, (-)-Lipstatin

Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product that was first isolated from the actinobacterium Streptomyces toxytricini.

Wikidata facts

Mass: 491.361074

Show 3 more facts

chemical formula: C₂₉H₄₉NO₅
canonical SMILES: CCCCCCC1C(OC1=O)CC(CC=CCC=CCCCCC)OC(=O)C(CC(C)C)NC=O
isomeric SMILES: CCCCCC[C@H]1[C@@H](OC1=O)C[C@H](C/C=C\C/C=C\CCCCC)OC(=O)[C@H](CC(C)C)NC=O

Sources (3)

via Wikidata · CC0

~2 min read

Article

3 sections

Contents

Biosynthesis
See also
References

Lipstatin is a potent, irreversible inhibitor of pancreatic lipase. It is a natural product that was first isolated from the actinobacterium Streptomyces toxytricini.

The popular antiobesity drug orlistat (trade names Xenical and alli) is a saturated derivative of lipstatin.